基本信息

　　姓名：张西锋  性别：男

　　学位：博士(后)   职称：教授，硕士生导师

　　bet356体育娱乐官网网站

　　联系电话：15318885978
                                    Email：zhangxf9465@163.com

　　教育背景：

　　张西锋，博士，教授，山东省郓城县人。青岛市十四届政协委员，致公党bet356体育娱乐官网网站支部主委，山东省肉牛遗传改良计划专家委员会委员，山东省第三次畜禽遗传资源普查专家组成员，中国细胞与分子显微技术学会会员。韩国Konkuk大学博士后，意大利Tor Vergata大学和中国科学技术大学访问学者。Phytomedicine和Int J Nanomed等十几种国际SCI刊物的特邀审稿人。

　　近年来，主持国家重点研发计划项目子课题、国家自然科学基金、山东省重点研发计划项目、湖北省自然科学基金和企业横向课题等10余项。在“Chemosphere”、 “Toxins”、和 “Int J Nanomed ”等期刊上以第一作者或通讯作者发表SCI收录文章39篇，他引3379次，h-index=28，高被引1篇（他引1847次）；授权国家发明专利13件；获省、市科研奖励4项。

　　近年来，指导毕业的研究生14名(其中4人次获得国家奖学金，3人次获得校优秀硕士毕业生，1人次获得校优秀毕业论文)，目前指导在读研究生7名。

　　近年来发表与完成的主要研究论文（“#”为共同第一作者；“*”为通讯作者）：

1. Tian Y#, Zhang Y#, Dong PY, Sun YH, Zhao AH, Shen W, Zhang XF*. Single-cell transcriptomic profiling to evaluate the effects of Di(2-ethylhexyl) phthalate exposure on early meiosis of female mouse germ cells. Chemosphere, 2022, 307:135698. (IF:8.943, 中科院杂志分区2区).
2. Chao HH#, Ma HH#, Sun JD, Yuan S, Dong PY, Zhao AH, Li L, Shen W, Zhang XF*. Whole-Transcriptome Analysis of Non-Coding RNA Alteration in Porcine Alveolar Macrophage Exposed to Aflatoxin B1. Toxins, 2022, 14:373. (IF:5.075, 中科院杂志分区2区)
3. Chao HH#, Wang L#, Ma HH, Zhao AH, Xiao HW, Zhang XF*. Identification of Apoptotic Pathways in Zearalenone-treated Mouse Sertoli Cells. J Toxicol Sci, 2022, 47(6):257-268. (IF:1.792, 中科院杂志分区4区)
4. Li WF#, Ma HH#, Dong PY, Liang CL, Li L, Zhang XF*. Construction of a Silver Nanoparticle Complex and its Application in Cancer Treatment. J Biomim Biomater Bi, 2022, 56:1-16. (EI、ESCI收录)
5. Yu QY, Yuan S, Yan YY, Zhang XF*. Extraction, preparation and an assessment of the activity of carboxymethyl polysaccharide from Panax japonicus. Food Sci Tech, 2022, 42, e82221. (IF:2.602, 中科院杂志分区4区，他引4次).
6. Yan YY, Wang Q, Sun LH, Zhang XF*. Extraction, preparation, and carboxymethyl of polysaccharide from Lotus Root. Food Sci Tech, 2022，42, e17822. (IF:2.602, 中科院杂志分区4区).
7. Yan YY, Yuan S, Zhao S, Xu CY, Zhang XF*. Preparation and Application of Phosphorylated Lotus Root Polysaccharide. Food Sci Tech, 2022, 42, e82121. (IF:2.602, 中科院杂志分区4区).
8. Li WF#, Ma HH#, Yuan S, Zhang XF*. Production of Pyracantha Polysaccharide-Iron (III) Complex and Its Biologic Activity. Molecules, 2021,  26(7): 1949. (IF:4.927, 中科院杂志分区3区，他引2次).
9. Yan YY, Yuan S, Ma HH, Zhang XF*. Structural Modification and Biological Activities of Carboxymethyl Pachymaran. Food Sci Nutr, 2021, 9:335-4348. (IF:3.553, 中科院杂志分区3区，他引1次) .
10. Feng G, Zhang XF*. Production of a Codonopsis Polysaccharide Iron Complex and Evaluation of its Properties. Int J Bio Mac, 2020, 162:1227-1240. (IF:6.953, 中科院杂志分区2区，他引6次).
11. Feng YN，Zhang XF*. Polysaccharide extracted from Huperzia serrata using response surface methodology and its biological activity. Int J Bio Mac, 2020，157:267-275. (IF:6.953, 中科院杂志分区2区，他引17次).
12. Yuan S, Xu CY, Xia J, Feng YN, Zhang XF*, Yan YY*. Extraction of polysaccharides from Codonopsis pilosula by fermentation with response surface methodology. Food Sci Nutr, 2020, 8(5), 6660-6669. (IF:2.863, 中科院杂志分区3区，他引10次)
13. Jian Li, Ding-Ping Bai, Zhang XF*. SNP discovery and functional annotation in the Panax japonicus var. major transcriptome. RSC advances, 2019, 9, 21513 - 21517. (IF:3.119, 中科院杂志分区3区，他引3次)
14. Wang LM, Yi Y, Shu CH, Yao YL, Feng G, Wang HX, Zhang XF*. Walnut oil improves spatial memory in rats and increases the expression of acid sensing ion channel genes, Asic2a and Asic4. Food Sci & Nutr, 2018,7(1):293-301.(IF:1.797, 中科院杂志分区4区，他引7次)
15. Bai DP, Lin XY, Huang YF, Zhang XF*. Theranostics aspects of various nanoparticles in Veterinary Medicine. Int J Mol Sci, 2018,19(11). pii: E3299. (IF:4.183,中科院杂志分区3区，他引50次)
16. Zhang XF, Huang FH, Zhang GL, Bai DP, De Felici M, Huang YF, Gurunathan S*. Novel biomolecule lycopene reduced graphene oxide-silver nanoparticles enhances apoptotic potential of trichostatin A in human ovarian cancer cells-SKOV3. Int J Nanomed, 2017,12:7551-7575.(IF:4.370，中科院杂志分区2区，他引50次)
17. Bai DP#, Zhang XF#, Zhang GL, Huang YF, Gurunathan S*. Zinc oxide nanoparticles induces apoptosis and autophagy in human ovarian cancer cells. Int J Nanomed, 2017,12:6521-6535.(IF:4.370，中科院杂志分区2区，他引166次)
18. Han Z, Yan Q, Ge W, Liu ZG, Gurunathan S, De Felici M, Shen W, Zhang XF*. Cytotoxic effects of ZnO nanoparticles on mouse testicular cells. Int J Nanomed, 2016, 11:5187-5203.(IF:4.3，中科院杂志分区1区，他引83次)
19. Zhang XF, Gurunathan S*. Combination of slinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: An effective anticancer therapy. Int J Nanomed, 2016, 11:3655-3675.(IF:4.3，中科院杂志分区1区，他引79次)
20. Zhang XF, Gurunathan S*. Biofabrication of a novel biomolecule-assisted reduced graphene oxide: An excellent biocompatible nanomaterial. Int J Nanomed, 2016, 11:6635-6649. (IF:4.3，中科院杂志分区1区，他引24次)
21. Zhang T, Shen W, De Felici M*, Zhang XF*. Di (2-ethylhexyl) phthalate: adverse effects on folliculogenesis that cannot be neglected. Environ Mol Mutagen, 2016, 57(8):579-588. (IF:3.575，中科院杂志分区3区，他引39次)
22. Zhang XF, Yan Q, Shen W, Gurunathan S*. Trichostatin A enhances apoptotic potential of palladium nanoparticles in human cervical cancer cells. Int J Mol Sci, 2016, 17(8),1354.(IF:3.226,中科院杂志分区3区，他引23次)
23. Zhang XF, Liu ZG, Shen W, Gurunathan S*. Silver Nanoparticles: Synthesis, characterization, properties, applications, and therapeutic approaches. Int J Mol Sci, 2016, 17(9):1534.(IF:3.226,中科院杂志分区3区，他引1847次)
24. Zhang XF, Shen W, Gurunathan S*. Silver nanoparticles mediated cellular responses in various cell lines: An in vitro model. Int J Mol Sci, 2016, 17(10): 1603. (IF:3.226,中科院杂志3区，他引207次)
25. Zhang XF, Shen W, Gurunathan S*. Biologically synthesized gold nanoparticles ameliorates cold and heat stress induced oxidative stress in Escherichia coli. Molecules, 2016, 21(6):731.(IF:2.861，中科院杂志分区3区，他引21次)
26. Wang LQ, Liu JC, Chen CL, Cheng SF, Sun XF, Zhao Y, Yin S, Hou ZM, Pan B, Ding C, Shen W, Zhang XF*. Regulation of primordial follicle recruitment by cross-talk between the Notch and phosphatase and tens in homologue (PTEN)/AKT pathways. Reprod Fert Develop, 2016, 28(6):700-712.(IF:2.656，中科院杂志分区3区，他引24次)
27. Sun XF, Sun XH, Cheng SF, Wang JJ, Feng YN, Zhao Y, Yin S, Hou ZM, Shen W, Zhang XF*. Interaction of the transforming growth factor-β and Notch signaling pathways in the regulation of granulosa cell proliferation. Reprod Fert Develop, 2016, 28(12):1873-1881. (IF:2.656，中科院杂志分区3区，他引9次)
28. Zhang XF, Park JH, Choi YJ, Kang MH, Gurunathan S, Kim JH*. Silver nanoparticles cause complications in pregnant mice. Int J Nanomed, 2015,10:7057-7071.(IF:4.320，中科院杂志分区2区, 他引56次)
29. Zhang XF, Gurunathan S, Kim JK*. Effects of silver nanoparticles on neonatal testis development in mice. Int J Nanomed, 2015,10:6243-6256. (IF:4.320，中科院杂志分区2区，他引42次)
30. Zhang XF#, Choi YJ#, Han JW, Kim E, Park JH, Gurunathan S, Kim JH*. Differential nanoreprotoxicity of silver nanoparticles in male somatic cells and spermatogonial stem cells. Int J Nanomed, 2015,10: 1335-1357. (IF:4.320，中科院杂志分区2区，他引89次)
31. Li L, Liu JC, Zhao Y, Lai FN, Yang F, Ge W, Dou CL, Shen W, Zhang XF*, Chen H*. Impact of diethylhexyl phthalate on gene expression and development of mammary glands of pregnant mouse. Histochem Cell Biol, 2015. 144(4):389-402. (IF:2.553,中科院杂志分区3区，他引15次)
32. Liang GJ#, Zhang XF#, Wang JJ#, Sun YC, Sun XF, Cheng SF, Li L, De Felicid M, Shen W*. ActivinA promote the meiotic initiation of female germ cells in mouse. Stem cell Dev, 2015, 24(20):2455-2465.(IF:3.777,中科院杂志分区2区)
33. Zhang XF, Zhang T, Han Z, Liu JC, Liu YP, Ma JY, Li L, Shen W*. Transgenerational inheritance of ovarian development deficiency induced by maternal diethylhexyl phthalate exposure. Reprod Fert Develop, 2015,27(8):1213-1221. (IF:2.135，中科院杂志分区3区，他引49次)
34. Li L, Zhang T, Qin XS, Ge W, Ma HG, Sun LL, Hou ZM, Chen H, Chen P, Qin GQ, Shen W, Zhang XF*. Exposure to Diethylhexyl phthalate (DEHP) results in a heritable modification of imprint genes DNA methylation in mouse oocytes. Mol Biol Rep, 2014 , 41(3):1227-1235. (IF:2.024，中科院杂志分区4区，他引89次)
35. Zhang XF, Zhang LJ, Li L, Feng YN, Chen B, Ma JM, Huynh E, Shi QH, De Felici M, Shen W*. Diethylhexyl Phthalate Exposure Impairs Follicular Developmentand and Affects Oocyte Maturation in the Mouse. Environ Mol Mutagen, 2013, 54(5):354-361. (IF:2.553，中科院杂志分区3区，他引109次)
36. Zhang XF, Zhang T, Wang L, Zhang HY, Chen YD, Qin XS, Feng YM, Feng YN, Shen W, Li L*. Effects of diethylhexyl phthalate (DEHP) given neonatally on spermatogenesis of mice. Mol Biol Rep, 2013,40(11):6509-6517. (IF:1.958，中科院杂志分区4区，他引42次)
37. Zhang GL#, Zhang XF#, Feng YM, Li L, Huynh E, Sun XF, Sun ZY, Shen W*. Exposure to bisphenol A results in a decline of spermatogenesis. Reprod Fert Develop, 2013,25(6):847-859. (IF:2.578，中科院杂志分区3区，他引67次)
38. Zhang XF, Zhang LJ, Feng YN, Chen B, Feng YM, Liang GJ, Li L, Shen W*. Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells. Mol Biol Rep, 2012,39 (9): 8621-8628. (IF:2.506，中科院杂志分区区，他引67次)
39. Zhang HQ#, Zhang XF#, Zhang LJ, Chao HH, Pan B, Feng YM, Li L, Sun XF, Shen W*. Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes, Mol Bio Rep，2012, 39(5): 5651 -5657. (IF:2.506，中科院杂志分区4区，他引125次)

　　授权的国家发明专利：

1. 张西锋，马浩海，李万芬，李兰，沈伟. 一种耐铜耐胆盐的菌株、益生菌菌剂及其应用, 专利号：ZL 202110569943.6
2. 张西锋，沈伟，李兰，李万芬. 纳米硒合成菌、纳米硒合成菌的筛选方法及其应用，专利号：ZL 202110566826.4
3. 袁帅，张西锋，李万芬，鄢又玉. 党参多糖铁复合物的制备方法及应用，专利号：ZL201910530623.2
4. 张西锋，舒畅，李万芬，鄢又玉. 硒化羧甲基茯苓多糖及其制备方法及应用，专利号：ZL 201910444693.6
5. 张西锋. 一种复合微生物菌吸附剂及其制备方法以及污水处理方法，专利号：ZL 201811421005.6
6. 张西锋，徐长远，李万芬，鄢又玉. 一种经修饰的千层塔多糖的制备方法及应用，专利号：ZL201910795458.3
7. 张西锋，夏洁，李万芬，鄢又玉. 千层塔多糖的提取方法，专利号：ZL 201910800020.X
8. 张西锋，姚依兰，冯阁，舒畅，王庆. 一种火棘多糖铁复合物的制备方法及其应用，专利号：ZL201811121104.2
9. 张西锋，李万芬. 一种纳米银复合物的制备方法及其应用，专利号：ZL 201811120863.7
10. 张西锋，袁帅，李万芬，鄢又玉. 羧甲基化莲藕多糖-曲古霉素A轭合物的制备方法，专利号：ZL 201910821088.6
11. 张西锋，赵帅，鄢又玉. 一种磷酸化莲藕多糖的制备方法及抗氧化剂或抗肿瘤药物，专利号：ZL 202010110576.9
12. 张西锋，李兰，张志鹏，沈伟. ActA促进减数分裂前雌性生殖细胞体外发育的技术方法，国家发明专利，专利号：ZL 201110341752.0
13. 朱闻君，赵小龙，杨涛，汤进，陈平，张绍鹏，张西锋，汪琪，李长玲，邓堔. 一种茯苓NADPH氧化酶编码基因Nox及其应用，国家发明专利，专利号：ZL 201410487383.X

　　获奖情况：

1. 指导的本科生俞启扬获得第二届全国大学生生物科学竞赛优胜奖，2018年12月；
2. 指导的本科生俞启扬获得湖北省第五届大学生生物实验技能竞赛荣获综合奖二等奖，湖北省大学生生物实验技能竞赛组委会，2018年9月26日；
3. 张西锋，湖北省第五批“博士服务团”工作先进个人，中共湖北省委组织部，共青团湖北省委，2017年3月；
4. 张西锋，金龙鱼青年教师奖，金龙鱼慈善公益基金会，2016年12月；
5. 张滕，张西锋，李兰，朝呼和，张国梁. 2014年山东省研究生优秀科技创新成果三等奖，山东省人民政府学位委员会，山东省教育厅，2014年6月；
6. 沈伟，张西锋，李兰，孙晓风. 2014年山东高等学校优秀科研成果奖（贰等奖），山东省教育厅，2014年9月；
7. 沈伟，李兰，孙晓风，张西锋，潘博. 动物卵母细胞体外发生及其表观遗传调节机制的研究，2012年山东省高等学校优秀科研成果奖（贰等奖），山东省教育厅，2012年12月；
8. 沈伟，李兰，孙晓风，张西锋，闵令江. 哺乳动物卵母细胞发生的分子调节机制，青岛市科技进步自然科学类（贰等奖），青岛市人民政府，2013年1月。